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江苏养殖技术创业人(吴圣龙，江苏泰州人，扬州大学研究员、博导，猪病专家)

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　　吴圣龙，江苏泰州人，扬州大学研究员、博导，扬州大学动物科学与技术学院党委书记。

一、研究方向

　　1、猪疾病抗性和免疫应答的调控机制

　　2、猪抗病育种和健康养殖

吴圣龙，江苏泰州人，扬州大学研究员、博导，猪病专家。

二、社会兼职

　　江苏省规模猪场高效健康养殖公共技术服务中心主任

　　江苏省生猪产业技术创新联盟副理事长

　　江苏省太湖猪基因库及保种项目首席专家

　　江苏省农业科技创新团队（东串猪选育）首席专家

三、学习、工作简历

　　1986年7月毕业于江苏农学院畜牧专业，获学士学位，同年留校。

　　2003年12月获扬州大学兽医专业硕士学位。

　　2006年12月获扬州大学动物遗传育种与繁殖学博士学位。

　　历任扬州大学动物科学与技术学院党委副书记、副院长、扬州大学科技处副处长、处长等职务

瘦西湖校区

四、科研项目

　　先后主持国家自然科学基金、国家转基因生物新品种培育科技重大专项、国家星火计划重点项目、江苏省科技支撑计划重点项目等科研项目20余项，其中国家级和部省级科研项目9项；获全国商业科技进步一等奖、全国农牧渔业丰收奖一等奖各1项。

五、科研项目

　　1、“FUT1基因启动子区对断奶仔猪大肠杆菌抗性的调控机制分析”（国家自然科学基金，31472066）

　　2、“鞘糖脂生物合成通路及关键基因对猪F18大肠杆菌抗性的调控机理研究”（国家自然科学基金，31172183）

　　3、“太湖猪F18大肠杆菌抗性主效基因的筛选与功能研究”（国家自然科学基金，30972089）

　　4、“抗仔猪腹泻病转基因猪新品系培育”（转基因生物新品种培育科技重大专项，2014ZX08006-001B）

　　5、“抗仔猪腹泻病转基因猪育种新材料创制”（转基因生物新品种培育科技重大专项，2009ZX08006-004B）

　　6、“家畜规模化高效健康养殖技术示范及推广”（国家星火计划重点项目，2012GA690003）

　　7、“地方特色土种猪新品系及配套系选育”（江苏省科技支撑计划重点项目，BE2014357）

　　8、“中梅山猪专门化母系选育及其与巴克夏猪杂交配套研究”（江苏省科技支撑计划，BE2013345）

　　9、 “苏太猪免疫应答评价体系建立及抗逆型配套系的培育”（江苏省科技支撑计划，BE2010371）

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六、省部级奖励

　　1、“猪无公害生态养殖关键技术研发与推广应用”（全国商业科技进步一等奖，2/15）

　　2、“江苏省挂县强农富民工程”（全国农牧渔业丰收奖一等奖，5/25）

　　3、“十一.五”高校科技管理先进个人（教育部）

荷花池校区

七、发表论文

　　近5年来带领课题组在Scientific Reports、Animal Genetics、PLos One、Gene、Int. J. Mol. Sci 、Journal of Genetics、中国农业科学、畜牧兽医学报、遗传、农业生物技术学报等国内外刊物上发表论文80余篇，其中SCI收录30篇，总影响因子超过60。

　　1、Zhengchang Wu, Ying Liu, Wenhua Dong, Guo-qiang Zhu, Shenglong Wu & Wenbin Bao. CD14 in the TLRs signaling pathway is associated with the resistance to E. coli F18 in Chinese domestic weaned piglets. Scientific Reports, 2016, 6:24611.

　　2、Sun L, Wang J, Yin X, Sun S, Zi C, Zhu G, Wu S, Bao W. Identification of a 5-Methylcytosine Site that may Regulate C/EBPβ Binding and Determine Tissue-Specific Expression of the BPI Gene in Piglets. Scientific Reports, 2016, 6: 28506.

　　3、Y. Liu, L.N. Gan, W.Y. Qin, S.Y. Sun, G.Q. Zhu, S.L. Wu, W.B. Bao. Differential expression of Toll-like receptor 4 signaling pathway genes in Escherichia coli F18-resistant and -sensitive Meishan piglets. Polish Journal of Veterinary Sciences, 2016, 19(2): 303-308.

　　4、 Dong WH, Dai CH, Sun L, Wang J, Sun SY, Zhu GQ, Wu SL, Bao WB. Expression of key glycosphingolipid biosynthesis-globo series pathway genes in Escherichia coli F18-resistant and Escherichia coli F18-sensitive piglets. Animal genetics, 2016, 47(4):428-435.

　　5、R.W. Xia, W.Y. Qin, L.N. Gan, J. Wang, S.L. Wu, W.B. Bao. Differential expression of FUT1 and FUT2 in Large White, Meishan, and Sutai porcine breeds. Genet Mol Res. 2016, 15(1): 15017613.

　　6、S. P. Zhu, X. M. Yin, L. Sun, S. Y. Sun, W. B. Bao, S. L. Wu. Differential expression of porcine TAP1 gene in different populations. Russian Journal of Genetics. 2015, 51(3): 308-312.

　　7、Wenhua Dong, Xuemei Yin, Li Sun, JingWang, Shouyong Sun, Guoqiang Zhu, ShenglongWu, Wenbin Bao. Age-associated methylation change of TAP1 promoter in piglet. Gene. 2015, 573: 70-74.

　　8、XueMei YIN, Ying LIU, WenHua DONG, QiaoHui ZHAO, GuoQiang ZHU, ShengLong WU, WenBin BAO. Association of Mx1 gene polymorphism with some economic traits in Meishan pigs. Turkish Journal of Veterinary and Animal Sciences. 2015, 39: 389-394.

　　9、Ying LIU, XueMei YIN, RiWei XIA, YongJiu HUO, GuoQiang ZHU, ShengLong WU, WenBin BAO. Association between the MUC4g.243A>G polymorphism and immune and production traits in Large White pigs. Turkish Journal of Veterinary and Animal Sciences. 2015, 39: 1-6.

　　10、Z.C. Wu, Y. Liu, W.H. Dong, Y. J. Huo, S. L. Wu, W.B. Bao. Identification of BPI protein produced in different expression system and its association with Escherichia coli F18 susceptibility. Genet Mol Res. 2015, 14(1): 1111-1123.

　　11、Z.C. Wu, Y. Liu, Q.H. Zhao, Y. J. Huo, S. L. Wu, W.B. Bao. Association of single nucleotide polymorphisms of exon 4 and exon 10 of the BPI gene with immune indexes in Sutai pigs. Genet Mol Res. 2015, 14(2): 6048-6058.

　　12、Zhengchang Wu, Riwei Xia, Xuemei Yin, YongjiuHuo, GuoqiangZhu, Shenglong Wu and Wenbin Bao .Proteomic analysis of duodenal tissuefromEscherichia coli F18-resistant and -susceptible weaned piglets. PLos One. 2015, 10(6): e0127163.

　　13、Qiaohui Zhao, Ying Liu, Wenhua Dong, Shiping Zhu, Yongjiu Huo, Shenglong Wu, Wenbin Bao. Genetic Variations of TAP1 Gene Exon 3 Affects Gene Expression and Escherichia coli F18 Resistance in Piglets. Int. J. Mol. Sci. 2014, 15: 11161-11171.

　　14、Jing Wang, Xuemei Yin, Li Sun, Shouyong Sun, Chen Zi, Guoqiang Zhu, Shenglong Wu, Wenbin Bao. Correlation between BPI Gene Upstream CpG Island Methylation and mRNA Expression in Piglets. Int. J. Mol. Sci. 2014, 15: 10989-10998.

　　15、J. Wang, Y. Liu, W.H. Dong, Y.J. Huo, X.G. Huang, S.L. Wu and W.B. Bao. Dynamic changes in TAP1 expression levels in newborn to weaning piglets, and its association with Escherichia coli F18 resistance. Genet Mol Res. 2014, 13(2): 3686-3692.

　　16、Shiping Zhu, Ying Liu, Wenhua Dong, Xianrui Zheng, Guoqiang Zhu, Shenglong Wu, Wenbin Bao. Polymorphism of FUT1 Gene M307 and its Relationship with Partial Immune Indexes and Economic Traits in Yorkshire Pigs. Asian Journal of Animal & Veterinary Advances. 2014, 9(4): 253-261.

　　17、Chen Zi, Zhengchang Wu, Jing Wang, Yongjiu Huo, Guoqiang Zhu, Shenglong Wu and Wenbin Bao. Transcriptional Activity of the FUT1 Gene Promoter Region in Pigs. Int. J. Mol. Sci. 2013, 14: 24126-24134.

　　18、Wang J, Pan ZY, Zheng XR, Wu ZC, Su XM, Zhu GQ, Huang XG, Wu SL, Bao WB. TLR4 gene expression in pig populations and its association with resistance to Escherichia coli F18. Genet Mol Res. 2013, 12(3): 2625-2632.

　　19、Lu Liu, Jing Wang, Qiaohui Zhao, Chen Zi, Zhengchang Wu, Xianmin Su a, Yongjiu Huo, Guoqiang Zhu, Shenglong Wu, Wenbin Bao. Genetic variation in exon 10 of the BPI gene is associated with Escherichia coli F18 susceptibility in Sutai piglets. Gene. 2013, 523(1): 70-75.

　　20、J. Zhu, C. Zi, Z.C. Wu, L. Liu, X.R. Zheng, X.M. Su, G.Q. Zhu, X.G. Huang, S.L. Wu and W.B. Bao. Age-dependent expression of the BPI gene in Sutai piglets. Genet Mol Res. 2013, 12(2): 2120-2126.

校友会2019年专业排名中我院动物科学专业名列全国第三

　　21、L. Ye, C. Zi, Z.Y. Pan, J. Zhu, Z.D. Du, G.Q. Zhu, X.G. Huang, W.B. Bao, S.L. Wu. Investigation of the relationship between SLA-1 and SLA-3 gene expression and susceptibility to Escherichia coli F18 in post-weaning pigs. Comparative Immunology, Microbiology and Infectious Diseases. 2012(35): 23–30.

　　22、Lan Ye, Xianmin Su, Zhengchang Wu, Xianrui Zheng, Jin Wang, Chen Zi, Guoqiang Zhu, Shenglong Wu, Wenbin Bao. Analysis of Differential miRNA Expression in theDuodenum of Escherichia coli F18-Sensitive and -Resistant Weaned Piglets. PLoS ONE. 2012, 7(8): e43741.

　　23、Wen-bin Bao, Lan Ye, Chen Zi, Lu Liu, Chen Zi, Jing Zhu, Zhang-yuan Pan, Guo-qiang Zhu, Xue-gen Huang, Sheng-long Wu. Relationship between the expression level of SLA-DQA and Escherichia coli F18 infection in piglets. Gene. 2012 (494): 140–144.

　　24、Wen-Bin Bao, Lan Ye, Chen Zi, Xian-Min Su, Zhang-Yuan Pan, Jin Zhu, Guo-Qiang Zhu, Xiao-Guo Huang, Sheng-Long Wu. Study on the age-dependent tissue expression of FUT1 gene in porcine and its relationship to E. coli F18 receptor, Gene. 2012 (497): 336–339.

　　25、Wen-bin Bao, Lan Ye, Zhang-yuan Pan, Jing Zhu, Zi-Dong Du, Guo-qiang Zhu, Xue-gen Huang, Sheng-long Wu. The effect of mutation at M307 in FUT1 gene on susceptibility of Escherichia coli F18 and genen Sutai piglets. Molecular Biology Reports. 2012, 39(3): 3131–3136.

　　26、Wen-bin Bao, Lan Ye, Jing Zhu, Zhang-yuan Pan, Guo-qiang Zhu, Xue-gen Huang, Sheng-long Wu. Evaluation of M307 of FUT1 gene as a genetic marker for disease resistance breeding of Sutai pigs. Molecular Biology Reports. 2012, 39(4): 4223–4228.

　　27、W. B. Bao, L. Ye, Z. Y. Pan, J. Zhu, Z. D. Du, G. Q. Zhu, X. G. Huang and S. L. Wu. Microarray analysis of differential gene expression in sensitive and resistant pig to Escherichia coli F18. Animal Genetics. 2012, 43(5): 525-534.

　　28、W. B. BAO, L. YE, Z. Y. PAN, J. ZhU, G. Q. ZhU, X. G. HUANG, S. L.WU. Analysis of polymorphism in the porcine TLR4 gene and its expression related to Escherichia coli F18 infection. Czech Journal of Animal Science. 2011, 56(11): 475–482.

　　29、W. B. Bao, L. Ye, J. Zhu, Z. Y. Pan, G. Q. Zhu, X. G. Huang & S. L. Wu. Beneficial genotype of swine FUT1 gene governing resistance to E. coli F18 is associated with important economic traits. Journal of Genetics. 2011, 90(2): 315–318.

　　30、WEN-Bin Bao, Lan Ye, ZHANG-Yuan Pan, Jin Zhu, GUO-Qiang Zhu, XUE-Gen Huang and SHENG-Long Wu. Polymorphism of M307 of the FUT1 gene and its relationship with some immune indexes in Sutai pigs (Duroc × Meishan). Biochemical Genetics. 2011, 49: 665–673.