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北京实验动物养殖场(侯卓成，中国农业大学动物科技学院教授，家禽遗传育种专家)

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　　侯卓成，中国农业大学动物科技学院教授，研究方向：动物基因组学与生物信息学，家禽遗传育种。

一、教授课程

　　主讲

　　本科：群体遗传学、家禽生产实习

　　硕士：动物基因组数据分析

　　参讲

　　本科：家禽生产学

　　硕士：畜禽基因组学

侯卓成，中国农业大学动物科技学院教授，家禽遗传育种专家。

二、学习工作简历

　　1995.9-2002.6，中国农业大学动物遗传育种专业本科，硕士

　　2001.7-8，参加全国第一界生物信息学研究生班（厦门大学），学习生物信息学

　　2002.7-8，参加全国分子群体遗传学与分子进化研究生班（中国科学院昆明动物研究所），学习生物信息学与分子群体遗传学

　　2004.9-2007.6，中国农业大学动物遗传育种专业博士

　　2007.10-2010.12，在美国NIH PRB，研究助理

　　2002.1-至今，先后担任中国农业大学动物科技学院助理研究员、副研究员、教授

三、社会兼职

　　国家水禽产业技术体系岗位科学家、全国水禽遗传改良计划专家组成员、中国畜牧兽医学会信息技术分会常务理事、农业农村部动物遗传育种与繁殖重点实验室（家畜）学科群主任助理、科技部畜禽种业创新战略联盟秘书等。

四、获奖

　　综合利用生物信息、功能基因组等多种手段阐明家禽重要经济性状的遗传基础。荣获北京科技进步一等奖，教育部科技进步二等奖，全国农牧渔业丰收一等奖，大北农青年学者奖，入选2016年学院青年英才培育计划（A类）等。

中国农业大学老校门

五、近5年主要承担课题

　　国家级、省部级课题

　　1、水禽种质资源创新与利用，国家科技支撑计划，主持,（2014.4-2019.12）

　　2、国家水禽产业技术体系岗位科学家（2017.1-2020.12）

　　3、蛋壳特异基质蛋白质OC-17表达调控网络构建及其对碳酸钙结晶作用的分子机理研究，主持，国家自然科学基金面上项目（31572388，2015.1-2019.12）

　　4、北京鸭皮下、腹脂前脂肪细胞分化能力差异的遗传基础研究，主持，国家自然科学基金面上项目（31972525，2020.1-2013。12）

　　5、北京鸭饲料性状分子标记，国家科技支撑计划子课题，主持（2011.1-2015.12）

　　6、优质北京鸭品种改良与选育，国家现代农业先导项目，北京科委，副主持（2014.1-2016.12）

　　7、北京鸭特色新品系培育及推广，国家现代农业先导项目，北京科委，副主持（2018.8-2021.12）

　　横向课题

　　主持北京鸭育种（2011-2025）、肉鸭性能测定设备升级咨询、畜禽遗传资源保护等。

　　战略研究课题

　　先后参与科技部、农业部、教育部、中国工程院等多项行业战略性调研等研究任务，参与起草了多项报告。

六、研究成果

　　1、发明专利

　　基于GBS技术的北京鸭简化基因测序方法（201610556456.5），侯卓成、朱峰等，第一完成人

　　一种用于鉴别鸡匍匐性状的引物组合及其应用（201610134746.0），侯卓成、杨宁等，第一完成人

　　2、软件著作登记权

　　北京鸭自动计量系统数据处理软件（NO.00869582）,2015，侯卓成、朱峰等，第一完成人

　　3、肉鸭性能测定设备

　　以第一完成人开发业界领先的肉禽自动化性能测定设备一套，该设备已经在多个国内主要家禽研究中心、育种企业使用。

中国农业大学侯卓成教授应邀到贵州大学动物科学学院指导教学科研工作。

　　4、主要论文列表

　　SCI期刊论文

　　1、Yin Z, Lian L, Zhu F, Zhang ZH, Hincke M, Yang N, Hou ZC: The transcriptome landscapes of ovary and three oviduct segments during chicken (Gallus gallus) egg formation. GENOMICS 2020, 112(1):243-251.

　　2、Zhu F, Cui QQ, Yang YZ, Hao JP, Yang FX, Hou ZC: Genome-wide association study of the level of blood components in Pekin ducks. GENOMICS 2020, 112(1):379-387.

　　3、Chen X, Li X, He Z, Hou Z, Xu G, Yang N, Zheng J: Comparative study of eggshell antibacterial effectivity in precocial and altricial birds using Escherichia coli. PLOS ONE 2019, 14(7):e220054.

　　4、Deng MT, Zhu F, Yang YZ, Yang FX, Hao JP, Chen SR, Hou ZC: Genome-wide association study reveals novel loci associated with body size and carcass yields in Pekin ducks. BMC GENOMICS 2019, 20(1):1.

　　5、Ding S, Li G, Chen S, Zhu F, Hao J, Yang F, Hou Z: Comparison of carcass and meat quality traits between lean and fat Pekin ducks. Asian-Australas J Anim Sci 2019.

　　6、Wang Z, Yin ZT, Zhang F, Li XQ, Chen SR, Yang N, Porter TE, Hou Z: Dynamics of transcriptome changes during subcutaneous preadipocyte differentiation in ducks. BMC GENOMICS 2019, 20(1):688.

　　7、Xing K, Zhao X, Ao H, Chen S, Yang T, Tan Z, Wang Y, Zhang F, Liu Y, Ni H et al: Transcriptome analysis of miRNA and mRNA in the livers of pigs with highly diverged backfat thickness. Sci Rep 2019, 9(1):16740.

　　8、Yan W, Sun C, Zheng J, Wen C, Ji C, Zhang D, Chen Y, Hou Z, Yang N: Efficacy of Fecal Sampling as a Gut Proxy in the Study of Chicken Gut Microbiota. FRONT MICROBIOL 2019, 10:2126.

　　9、Yin ZT, Zhu F, Lin FB, Jia T, Wang Z, Sun DT, Li GS, Zhang CL, Smith J, Yang N et al: Revisiting avian 'missing' genes from de novo assembled transcripts. BMC GENOMICS 2019, 20(1):4.

　　10、Yin Z, Zhang F, Smith J, Kuo R, Hou ZC: Full-length transcriptome sequencing from multiple tissues of duck, Anas platyrhynchos. SCI DATA 2019, 6(1):275.

　　11、Zhu F, Cheng SR, Yang YZ, Hao JP, Yang FX, Hou ZC: Genome-Wide Association Study of Growth and Feeding Traits in Pekin Ducks. FRONT GENET 2019, 10:702.

　　12、Zhu F, Zhang F, Hincke M, Yin ZT, Chen SR, Yang N, Hou ZC: iTRAQ-Based Quantitative Proteomic Analysis of Duck Eggshell During Biomineralization. PROTEOMICS 2019, 19(11):e1900011.

　　13、Hou Z, An L, Han J, Yuan Y, Chen D, Tian J: Revolutionize livestock breeding in the future: an animal embryo-stem cell breeding system in a dish. J Anim Sci Biotechnol 2018, 9:90.

　　14、Lin FB, Zhu F, Hao JP, Yang FX, Hou ZC: In vivo prediction of the carcass fatness using live body measurements in Pekin ducks. Poult Sci 2018, 97(7):2365-2371.

　　15. Wu Y, Zhang Y, Hou Z, Fan G, Pi J, Sun S, Chen J, Liu H, Du X, Shen J et al: Population genomic data reveal genes related to important traits of quail. GIGASCIENCE 2018, 7(5).

　　16、Xie S, Yang X, Wang D, Zhu F, Yang N, Hou Z, Ning Z: Thyroid transcriptome analysis reveals different adaptive responses to cold environmental conditions between two chicken breeds. PLOS ONE 2018, 13(1):e191096.

　　17、Liu L, Fan Y, Zhang Z, Yang C, Geng T, Gong D, Hou Z, Ning Z: Analysis of gene expression and regulation implicates C2H9orf152 has an important role in calcium metabolism and chicken reproduction. ANIM REPROD SCI 2017, 176:1-10.

　　18、Shi S, Shen Y, Zhang S, Zhao Z, Hou Z, Zhou H, Zou J, Guo Y: Combinatory Evaluation of Transcriptome and Metabolome Profiles of Low Temperature-induced Resistant Ascites Syndrome in Broiler Chickens. Sci Rep 2017, 7(1):2389.

　　19、Shi S, Shen Y, Zhang S, Zhao Z, Hou Z, Zhou H, Zou J, Guo Y: Combinatory Evaluation of Transcriptome and Metabolome Profiles of Low Temperature-induced Resistant Ascites Syndrome in Broiler Chickens. Sci Rep 2017, 7(1):2389.

　　20、Weckle A, McGowen MR, Xing J, Chen C, Sterner KN, Hou ZC, Romero R, Wildman DE: Ancestral resurrection of anthropoid estrogen receptor beta demonstrates functional consequences of positive selection. MOL PHYLOGENET EVOL 2017, 117:2-9.

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　　21、Zhu F, Gao Y, Lin F, Hao J, Yang F, Hou Z: Systematic analysis of feeding behaviors and their effects on feed efficiency in Pekin ducks. J Anim Sci Biotechnol 2017, 8:81.

　　22、Jin S, Zhu F, Wang Y, Yi G, Li J, Lian L, Zheng J, Xu G, Jiao R, Gong Y et al: Deletion of Indian hedgehog gene causes dominant semi-lethal Creeper trait in chicken. Sci Rep 2016, 6:30172.

　　23、Lipovich L, Hou ZC, Jia H, Sinkler C, McGowen M, Sterner KN, Weckle A, Sugalski AB, Pipes L, Gatti DL et al: High-throughput RNA sequencing reveals structural differences of orthologous brain-expressed genes between western lowland gorillas and humans. J COMP NEUROL 2016, 524(2):288-308.

　　24、Tan K, An L, Miao K, Ren L, Hou Z, Tao L, Zhang Z, Wang X, Xia W, Liu J et al: Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization. Proc Natl Acad Sci U S A 2016, 113(12):3197-3202.

　　25、Xing K, Zhu F, Zhai L, Chen S, Tan Z, Sun Y, Hou Z, Wang C: Identification of genes for controlling swine adipose deposition by integrating transcriptome, whole-genome resequencing, and quantitative trait loci data. Sci Rep 2016, 6:23219.

　　26、Xing K, Zhu F, Zhai L, Liu H, Wang Y, Wang Z, Chen S, Hou Z, Wang C: Integration of transcriptome and whole genomic resequencing data to identify key genes affecting swine fat deposition. PLOS ONE 2015, 10(4):e122396.

　　27、Zhao H, Sui L, Miao K, An L, Wang D, Hou Z, Wang R, Guo M, Wang Z, Xu J et al: Comparative analysis between endometrial proteomes of pregnant and non-pregnant ewes during the peri-implantation period. J Anim Sci Biotechnol 2015, 6(1):18.

　　28、Zhu F, Yuan JM, Zhang ZH, Hao JP, Yang YZ, Hu SQ, Yang FX, Qu LJ, Hou ZC: De novo transcriptome assembly and identification of genes associated with feed conversion ratio and breast muscle yield in domestic ducks. ANIM GENET 2015, 46(6):636-645.

　　29、Li G, Li D, Yang N, Qu L, Hou Z, Zheng J, Xu G, Chen S: A genome-wide association study identifies novel single nucleotide polymorphisms associated with dermal shank pigmentation in chickens. Poult Sci 2014, 93(12):2983-2987.

　　30、Shi S, Shen Y, Zhao Z, Hou Z, Yang Y, Zhou H, Zou J, Guo Y: Integrative analysis of transcriptomic and metabolomic profiling of ascites syndrome in broiler chickens induced by low temperature. MOL BIOSYST 2014, 10(11):2984-2993.

中国农业大学校徽

　　31、Sipahi L, Uddin M, Hou ZC, Aiello AE, Koenen KC, Galea S, Wildman DE: Ancient evolutionary origins of epigenetic regulation associated with posttraumatic stress disorder. FRONT HUM NEUROSCI 2014, 8:284.

　　32、Sui L, An L, Tan K, Wang Z, Wang S, Miao K, Ren L, Tao L, He S, Yu Y et al: Dynamic proteomic profiles of in vivo- and in vitro-produced mouse postimplantation extraembryonic tissues and placentas. BIOL REPROD 2014, 91(6):155.

　　33、Xing K, Zhu F, Zhai L, Liu H, Wang Z, Hou Z, Wang C: The liver transcriptome of two full-sibling Songliao black pigs with extreme differences in backfat thickness. J Anim Sci Biotechnol 2014, 5(1):32.

　　34、Zhang Q, Liu L, Zhu F, Ning Z, Hincke MT, Yang N, Hou Z: Integrating de novo transcriptome assembly and cloning to obtain chicken Ovocleidin-17 full-length cDNA. PLOS ONE 2014, 9(3):e93452.

　　35、Fan YF, Hou ZC, Yi GQ, Xu GY, Yang N: The sodium channel gene family is specifically expressed in hen uterus and associated with eggshell quality traits. BMC GENET 2013, 14:90.

　　36、Jie H, Lian L, Qu LJ, Zheng JX, Hou ZC, Xu GY, Song JZ, Yang N: Differential expression of Toll-like receptor genes in lymphoid tissues between Marek's disease virus-infected and noninfected chickens. Poult Sci 2013, 92(3):645-654.

　　37、Nie J, An L, Miao K, Hou Z, Yu Y, Tan K, Sui L, He S, Liu Q, Lei X et al: Comparative analysis of dynamic proteomic profiles between in vivo and in vitro produced mouse embryos during postimplantation period. J PROTEOME RES 2013, 12(9):3843-3856.

　　38、Wang Y, Wang C, Hou Z, Miao K, Zhao H, Wang R, Guo M, Wu Z, Tian J, An L: Comparative analysis of proteomic profiles between endometrial caruncular and intercaruncular areas in ewes during the peri-implantation period. J Anim Sci Biotechnol 2013, 4(1):39.

　　39、Yuan J, Wang B, Huang Z, Fan Y, Huang C, Hou Z: Comparisons of egg quality traits, egg weight loss and hatchability between striped and normal duck eggs. Br Poult Sci 2013, 54(2):265-269.

　　40、Hou ZC, Sterner KN, Romero R, Than NG, Gonzalez JM, Weckle A, Xing J, Benirschke K, Goodman M, Wildman DE: Elephant transcriptome provides insights into the evolution of eutherian placentation. GENOME BIOL EVOL 2012, 4(5):713-725.

　　41、Hou ZC, Yang FX, Qu LJ, Zheng JX, Brun JM, Basso B, Pitel F, Yang N, Xu GY: Genetic structure of Eurasian and North American mallard ducks based on mtDNA data. ANIM GENET 2012, 43(3):352-355.

　　42、Lu Y, Chen SR, Liu WB, Hou ZC, Xu GY, Yang N: Polymorphisms in Wnt signaling pathway genes are significantly associated with chicken carcass traits. Poult Sci 2012, 91(6):1299-1307.

　　43、Jameson NM, Hou ZC, Sterner KN, Weckle A, Goodman M, Steiper ME, Wildman DE: Genomic data reject the hypothesis of a prosimian primate clade. J HUM EVOL 2011, 61(3):295-305.

　　44、Wildman DE, Uddin M, Romero R, Gonzalez JM, Than NG, Murphy J, Hou ZC, Fritz J: Spontaneous abortion and preterm labor and delivery in nonhuman primates: evidence from a captive colony of chimpanzees (Pan troglodytes). PLOS ONE 2011, 6(9):e24509.

　　45、Zhang Y, Hou ZC, Chen ZX, Zheng JX, Chen SR, Qu LJ, Li JY, Xu GY, Yang N: Low-density lipoprotein receptor-related protein 2 gene is associated with egg-quality traits in dwarf layers. Poult Sci 2011, 90(12):2718-2722.

　　46、Goodman M, Sterner KN, Islam M, Uddin M, Sherwood CC, Hof PR, Hou ZC, Lipovich L, Jia H, Grossman LI et al: Phylogenomic analyses reveal convergent patterns of adaptive evolution in elephant and human ancestries. Proc Natl Acad Sci U S A 2009, 106(49):20824-20829.

　　47、Hou ZC, Romero R, Wildman DE: Phylogeny of the Ferungulata (Mammalia: Laurasiatheria) as determined from phylogenomic data. MOL PHYLOGENET EVOL 2009, 52(3):660-664.

　　48、Hou ZC, Yang N, Li JY, Xu GY: [Egg quality prediction by using Fourier transform near infrared reflectance spectroscopy (FT-NIR)]. Guang Pu Xue Yu Guang Pu Fen Xi 2009, 29(8):2063-2066.

　　49、Hou Z, Romero R, Uddin M, Than NG, Wildman DE: Adaptive history of single copy genes highly expressed in the term human placenta. GENOMICS 2009, 93(1):33-41.

　　50、Qu L, Liu W, Yang F, Hou Z, Zheng J, Xu G, Yang N: Origin and domestication history of Peking ducks deltermined through microsatellite and mitochondrial marker analysis. Sci China C Life Sci 2009, 52(11):1030-1035.

侯卓成，中国农业大学动物科技学院教授，家禽遗传育种专家。

　　51、Than NG, Romero R, Goodman M, Weckle A, Xing J, Dong Z, Xu Y, Tarquini F, Szilagyi A, Gal P et al: A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. Proc Natl Acad Sci U S A 2009, 106(24):9731-9736.

　　52、Than NG, Romero R, Erez O, Weckle A, Tarca AL, Hotra J, Abbas A, Han YM, Kim SS, Kusanovic JP et al: Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance. Proc Natl Acad Sci U S A 2008, 105(41):15819-15824.

　　53、Hou ZC, Xu GY, Su Z, Yang N: Purifying selection and positive selection on the myxovirus resistance gene in mammals and chickens. GENE 2007, 396(1):188-195.

　　54、Li XY, Qu LJ, Hou ZC, Yao JF, Xu GY, Yang N: Genomic structure and diversity of the chicken Mx gene. Poult Sci 2007, 86(4):786-789.

　　55、Qu L, Li X, Xu G, Chen K, Yang H, Zhang L, Wu G, Hou Z, Xu G, Yang N: Evaluation of genetic diversity in Chinese indigenous chicken breeds using microsatellite markers. Sci China C Life Sci 2006, 49(4):332-341.

　　56、Zhan K, Hou ZC, Li HF, Xu GY, Zhao R, Yang N: Molecular cloning and expression of the duplicated thyroid hormone responsive spot 14 (THRSP) genes in ducks. Poult Sci 2006, 85(10):1746-1754.

　　57、Zhang LC, Ning ZH, Xu GY, Hou ZC, Yang N: Heritabilities and genetic and phenotypic correlations of egg quality traits in brown-egg dwarf layers. Poult Sci 2005, 84(8):1209-1213.

　　58、Hou ZC, Yang N: Factors affecting codon usage in Yersinia pestis. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 2003, 35(6):580-586.

　　59、Hou ZC, Yang N: [Advances in major histocompatibility complex research in poultry]. Yi Chuan 2002, 24(1):72-76.

　　60、Hou ZC, Yang N: [Analysis of factors shaping S. pneumoniae codon usage]. Yi Chuan Xue Bao 2002, 29(8):747-752.

　　中文核心期刊

　　1、侯卓成.水禽育种技术以及自主化品种培育研究进展[J].养禽与禽病防治,2019(06):32-35.

　　2、杨宇泽,侯卓成,常卓,张权.北京鸭群体遗传多样性及遗传资源分析[J].中国畜牧杂志,2019,55(05):35-40.

　　3、林芳斌,崔倩倩,袁建敏,侯卓成.不同能蛋水平免填饲料对北京鸭皮脂性能的影响及性状相关分析[J].中国家禽,2016,38(14):22-26.

　　4、朱峰,王炎耘,郝金平,张金奉,杨宇泽,杨方喜,陈瑶,胡胜强,侯卓成.北京鸭骨质量性状和屠体性状的相关性研究[J].中国畜牧杂志,2015,51(23):1-5.

　　5、王炎耘,郝金平,李国程,袁建敏,杨方喜,陈瑶,胡胜强,侯卓成.日粮中添加不同比例纤维素对北京鸭生产性能的影响[J].中国家禽,2015,37(22):35-37.

　　6、朱峰,王炎云,郝金平,杨宇泽,李国臣,杨方喜,陈瑶,胡胜强,侯卓成.超声波法测量北京鸭皮脂性状及其与屠宰性状的相关分析[J].中国家禽,2015,37(16):6-9.

　　7、侯卓成. 我国水禽育种研究综述[N]. 中国畜牧兽医报,2014-11-16(012).

　　8、侯卓成. 养殖模式决定水禽育种方向[N]. 中国畜牧兽医报,2014-11-16(012).